Is Melatonin Protective in Contrast Material Related Renal Failure?

Protective Effects of Crocin against Cisplatin-Induced Acute Renal Failure and Oxidative Stress in Rats

Background. The major side effect of cisplatin, used in some tumours, is nephrotoxicity. Reactive oxygen species and oxidative damage are the most important factors in cisplatin-induced acute renal failure. The main purpose of this study is to investigate the protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rat. Methods. In this study, animal...

Renal failure after radiological contrast media.

Over a 12-month period four patients developed acute renal failure after undergoing radiological investigations using contrast media. Though the incidence of serious complications is low, the possibility of adverse side effects must be weighed against the usefulness of the information provided by these techniques.

Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice.

Fractalkine (CX3CL1) is expressed on injured endothelial cells and is a potent chemoattractant and adhesion molecule for macrophages carrying the fractalkine receptor (CX3CR1). The aim of this study was to investigate the role of CX3CL1, and its ligand CX3CR1, in ischemic acute renal failure (ARF) in mice. On immunoblotting, CX3CL1 protein expression in the kidney increased markedly in ischemic...

hepatitis c, chronic renal failure, control is possible!

Kidney protective effects of melatonin

*Corresponding author: Maryam Tavakoli M.D, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Email: [email protected] Melatonin is a hormone produced in the pineal gland. Melatonin is produced of tryptophan and serotonin and is metabolized to 6-hydroxyl melatonin in the liver (1-3). Melatonin is a highly important antioxidant. Free radicals damages cells...